HCID 178419017, compound → HCID 178518717, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-chloro-2′-deoxyinosine (6.0 g, 20.97 mmol) and histamine (4.4 g, 40 mmol) in 2-methoxyethanol (60 ml) was heated in a steel bomb at 110° C. for 12 hrs. The bomb was cooled to 0° C., opened carefully and the precipitated solid was filtered. The solid was washed with methanol and acetone and crystallized from DMF/water to give 6 g (79%) of pure 125. mp 220-222° C.

Provenance & Evidence