Diisopropyl Ether → HCID 10890457, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of racemic 2-(pentyl)-2-cyclopenten-1-ol (100 mg; 0.649 mmol), dimethylmalonate (100 mg; 0.757 mmol), ground KHCO3 (7 mg; 0.05 mmol), diisopropyl ether (1.8 ml) and lipase (100 mg) was stirred in a 10 ml flask at room temperature (20-23° C.). Results are shown in the table below. The reaction was followed by GC method and the ee was determined by treating samples collected at the times indicated with N-methyl-N-trimethylsilyl-trifluoracetamide in dipropyl ether to silylate unreacted alcohol and effecting a chiral GC analysis (Megadex 5).

Provenance & Evidence