Ammonia → 4-Cyanobenzaldehyde

Participants

Reaction Steps

13.2 g of p-cyanobenzylamine, 51 g of a 35% aqueous formalin solution and 24 g of a 28% aqueous ammonia solution were reacted at 90° C. for 2 hours while stirring in a solvent of which pH was adjusted to 3 by sulfuric acid. The reaction solution was cooled to room temperature and then cooled on ice for 2 hours. The crystals precipitated were collected by filtration, washed with water and dried to obtain 5.2 g (yield: 40%) of p-cyanobenzaldehyde. The p-cyanobenzaldehyde obtained had a purity of 99.5% or more determined by the analysis of high performance liquid chromatography.

Provenance & Evidence