1,4-Dicyanobenzene → 4-(Aminomethyl)benzonitrile
Reaction equation
[H][H].[C:3](#[N:12])[C:4]1[CH:11]=[CH:10][C:7]([C:8]#[N:9])=[CH:6][CH:5]=1>[Ni]>[C:8]([C:7]1[CH:10]=[CH:11][C:4]([CH2:3][NH2:12])=[CH:5][CH:6]=1)#[N:9]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
168 kg of p-cyanobenzylamine crude product (p-cyanobenzylamine 92% by weight, p-xylylenediamine 8% by weight) obtained by hydrogen reduction of terephthalonitrile in the presence of sponge metal nickel catalyst was mixed with 680 kg of water while stirring at 40° C. or less and the mixture was stirred for 3 hours. The crystals which precipitated were separated by centrifugation while washing with water to obtain 155 kg of p-cyanobenzylamine hydrate (water content: 21% by weight).
Sources & evidence
- ORD record
- ord-dc12ae195623466a92182027117bceaa
- Source dataset
- uspto-grants-2001_07
- Patent number
- US06262292B1
Reaction notes
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