(4-Chlorophenyl)acetic acid → 2-[(4chlorophenyI)acetamido]butyric acid iso-butyl ester

HRID 1385671Notes

Reaction equation

HRID 1385671 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=O)=[CH:4][CH:3]=1.[NH2:12][CH:13]([CH2:21][CH3:22])[C:14]([O:16][CH2:17][CH:18]([CH3:20])[CH3:19])=[O:15]>>[CH2:17]([O:16][C:14](=[O:15])[CH:13]([NH:12][C:9](=[O:11])[CH2:8][C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=1)[CH2:21][CH3:22])[CH:18]([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 15880(4-Chlorophenyl)acetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 540487372-[(4chlorophenyI)acetamido]butyric acid iso-butyl ester

Procedure

Following General Procedure I′ above and using 4-chlorophenylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure J′ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-b9376600d0f14837b70dad187e022e90
Source dataset
uspto-grants-2001_07
Patent number
US06262302B1

Reaction notes

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