2-(3-Methyl-1,2-oxazol-5-yl)acetic acid → N-[(3-methylisoxazol-5yl)acetyl]alanine Iso-butyl Ester

HRID 1385690Notes

Reaction equation

HRID 1385690 reaction equation
[CH3:1][C:2]1[CH:6]=[C:5]([CH2:7][C:8]([OH:10])=O)[O:4][N:3]=1.[CH2:11]([O:15][C:16](=[O:20])[C@H:17]([CH3:19])[NH2:18])[CH:12]([CH3:14])[CH3:13]>>[CH2:11]([O:15][C:16](=[O:20])[C@H:17]([CH3:19])[NH:18][C:8](=[O:10])[CH2:7][C:5]1[O:4][N:3]=[C:2]([CH3:1])[CH:6]=1)[CH:12]([CH3:14])[CH3:13]

Participants

3

Reactant 2

HCID 41955322-(3-Methyl-1,2-oxazol-5-yl)acetic acidHCID 137435562-methylpropyl (2S)-2-aminopropanoate

Product 1

HCID 15481782N-[(3-methylisoxazol-5yl)acetyl]alanine Iso-butyl Ester

Procedure

Following General Procedure I′ above, and using (3-methyl-isoxazol-5-yl)acetic acid (CAS# 19668-85-0) and alanine iso-butyl ester (prepared following General Procedure J′ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-6867ae7ba48d4e648858a2fdeaeaa501
Source dataset
uspto-grants-2001_07
Patent number
US06262302B1

Reaction notes

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