2-methylpropyl (2S)-2-aminopropanoate → N-[(6methoxybenzothiophen-2-yl)acetyl]alanine iso-butyl ester

HRID 1385691Notes

Reaction equation

HRID 1385691 reaction equation
[CH3:1][O:2][C:3]1[CH:15]=[CH:14][C:6]2[CH:7]=[C:8]([CH2:10][C:11]([OH:13])=O)[S:9][C:5]=2[CH:4]=1.[CH2:16]([O:20][C:21](=[O:25])[C@H:22]([CH3:24])[NH2:23])[CH:17]([CH3:19])[CH3:18]>>[CH2:16]([O:20][C:21](=[O:25])[C@H:22]([CH3:24])[NH:23][C:11](=[O:13])[CH2:10][C:8]1[S:9][C:5]2[CH:4]=[C:3]([O:2][CH3:1])[CH:15]=[CH:14][C:6]=2[CH:7]=1)[CH:17]([CH3:19])[CH3:18]

Participants

3

Reactant 2

HCID 137435562-methylpropyl (2S)-2-aminopropanoateHCID 22491908(6-Methoxybenzothiophen-2-yl)acetic acid

Product 1

HCID 22894977N-[(6methoxybenzothiophen-2-yl)acetyl]alanine iso-butyl ester

Procedure

Following General Procedure I′ above, and using (6-methoxybenzothiophen-2-yl)acetic acid and alanine iso-butyl ester (prepared following General Procedure J′ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-da2ad5369c31463daa41ab832e48ffd8
Source dataset
uspto-grants-2001_07
Patent number
US06262302B1

Reaction notes

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