HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-Carboxymethyl-naphthalen-1-yl)-acetic acid → HCID 54246484, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-Carboxymethyl-naphthalen-1-yl)-acetic acid | HCID 22717309 | — |
| Reactant | benzyl (2R)-pyrrolidine-2-carboxylate hydrochloride | HCID 22827650 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 54246484 | HCID 54246484 | 75% |
Reaction Steps
Using General Procedure A with 200 mg (0.82 mmol) D-Proline benzyl ester hydrochloride and 100 mg (0.41 mmol) (4-carboxymethyl-naphthalen-1-yl)-acetic acid afforded, after flash chromatography (EtOAc), 188 mg (75%) of the title compound as a colorless oil. MS m/e (%): 636 (M+NH4+, 100), 619 (M+H+, 75).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06262089B1 |
| Source dataset | uspto-grants-2001_07 |
| ORD ID | ord-4208d78815ca4a1eb405954526f589ea |
| Source note | uspto-grants-2001_07 |