HCID 86588285, compound → HCID 86757161, compound

HRID 1385770Notes

Reaction equation

HRID 1385770 reaction equation
C([O:8][C:9]([C@H:11]1[CH2:15][CH2:14][CH2:13][N:12]1[C:16](=[O:40])/[C:17](/[CH3:39])=[CH:18]/[CH:19]=[C:20](\[CH3:38])/[C:21]([N:23]1[CH2:27][CH2:26][CH2:25][C@@H:24]1[C:28]([O:30]CC1C=CC=CC=1)=[O:29])=[O:22])=[O:10])C1C=CC=CC=1>O1CCOCC1>[C:28]([C@H:24]1[CH2:25][CH2:26][CH2:27][N:23]1[C:21](=[O:22])[C:20]([CH3:38])=[CH:19][CH:18]=[C:17]([CH3:39])[C:16]([N:12]1[CH2:13][CH2:14][CH2:15][CH:11]1[C:9]([OH:10])=[O:8])=[O:40])([OH:30])=[O:29]

Participants

3

Reactant 1

HCID 86588285HCID 86588285, compound

Product 1

HCID 86757161HCID 86757161, compoundYield 16.7%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Using General Procedure B with 1.14 g (2.09 mmol) (2E,4E)-(R)-1-[6-[(R)-2-Benzyloxycarbonyl-pyrrolidin-1-yl]-2,5-dimethyl-6-oxo-hexa-2,4-dienoyl]-pyrrolidine-2-carboxylic acid benzyl ester and with dioxane as solvent afforded 127 mg (16%) of the title compound as a white solid. MS m/e (%): 365 (M+H+, 100).

Sources & evidence

ORD record
ord-6312dd395eb5472e9a1de41d4df7927c
Source dataset
uspto-grants-2001_07
Patent number
US06262089B1

Reaction notes

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