Malonic acid, disodium salt → Bicyclo[2,2,2]oct-5-ene-2-carbonyl malonic acid

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Reaction Steps

To a solution containing sodium malonate (17.1 g) which was prepared according to the same procedure as in Example 7, bicyclo[2,2,2]oct-5-ene-2-carbonyl chloride (17.1 g) obtained in Preparation Example 2 is slowly added, and the reaction mixture is reacted at −20° C. in a nitrogen atmosphere for 1 hour, and further reacted at 60° C. for 9 hours. Then, the mixture is worked up as in the procedure of Example 1, to obtain 21 g of the pure title compound (purity: 99%, yield: 88%).

Provenance & Evidence