反应详情

To a solution containing sodium malonate (17.1 g) which was prepared according to the same procedure as in Example 7, bicyclo[3,2,2]non-8-ene-2-carbonyl chloride (18.4 g) obtained in Preparation Example 3 is slowly added, and the reaction mixture is reacted at −20° C. in a nitrogen atmosphere for 1 hour, and further reacted at 45° C. for 8 hours. Then, the mixture is worked up as in the procedure of Example 1, to obtain 22 g of the pure title compound (purity: 99%, yield: 87%).

1. customwas prepared
2. customobtained in Preparation Example 3
3. additionis slowly added
4. customthe reaction mixture is reacted at −20° C. in a nitrogen atmosphere for 1 hour
5. customfurther reacted at 45° C. for 8 hours