Sodium Chloride → HCID 21716203, compound

Participants

Reaction Steps

2.32 g (16.81 mmoles) of potassium carbonate are added to a solution prepared with 5 g (15.28 mmoles) of 4-chloro-3-(4-chloro-2-fluoro-5-hydroxyphenyl)-5-difluoromethoxy-1-methylpyrazole, 3.92 g (16.81 mmoles) of ethyl 2-bromomethyl-3-furancarboxylate and 100 ml of acetone. The mixture is heated to reflux temperature under stirring for 2 hours. The raw product is then poured into 500 ml of a saturated solution of sodium chloride and extracted with ethyl acetate (3×150). The joined organic phases are washed with a saturated solution of sodium chloride, anhydrified with sodium sulfate and concentrated under vacuum. The raw product is purified by means of silica gel chromatography using a mixture of hexane/ethyl acetate: 8/2 as eluant. 7.18 g of ethyl 2-[2-chloro-5-(4-chloro-5-difluoromethoxy-1-methylpyrazol-3-yl)-4-fluorophenoxymethyl]-3-furancarboxylate (Compound Nr. 2) are obtained (yield 98%), as a white solid having a melting point of 59-61° C.

Provenance & Evidence