Sodium Hydroxide → HCID 21716272, compound

Participants

Reaction Steps

A solution of 5.8 g (18 mmol) of 5-chloro6-ethyl4-(6-methoxytetralin-2-ylamino)pyrimidine in 22 ml of 48% HBr and 4.5 ml of acetic acid was heated for 4 hours at 110° C. After the mixture had cooled, it was brought to pH=8 with sodium hydroxide solution and extracted with dichloromethane. After the dichloromethane phase had been dried, concentrated and washed with toluene, 4.8 g (88% of theory) of colorless crystals were obtained (m.p. 178° C.).

Provenance & Evidence