Sodium Hydroxide → HCID 18518702, compound

HRID 1385977Notes

Reaction equation

HRID 1385977 reaction equation
[OH-].[Na+].C([O:5][C:6]([C:8]1([OH:19])[C:16]2[C:11](=[C:12]([O:17][CH3:18])[CH:13]=[CH:14][CH:15]=2)[CH2:10][CH2:9]1)=[O:7])C>CCO.[Cl-].[Na+].O>[OH:19][C:8]1([C:6]([OH:7])=[O:5])[C:16]2[C:11](=[C:12]([O:17][CH3:18])[CH:13]=[CH:14][CH:15]=2)[CH2:10][CH2:9]1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 54008058HCID 54008058, compound

Product 1

HCID 18518702HCID 18518702, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 57417360Sodium chloride; waterSolvent

Procedure

NaOH (19M; 1.0 mL) was added to a solution of 1-hydroxy-4-methoxyindan-1-yl-carboxylic acid ethyl ester (0.90 g; 3.8 mmol; from step (ii) above) in EtOH (20 mL) and the solution was stirred for 30 minutes. Brine (40 mL) was added and the mixture was washed with EtOAc, cautiously made acidic to pH 2 (HCl; 2M), and the aqueous solution was extracted with EtOAc. The organic layer was washed with brine, dried (Na2SO4) and concentrated, yielding 0.70 g (88%) of the sub-title substance.

Workup

  1. washthe mixture was washed with EtOAc, cautiously made acidic to pH 2 (HCl; 2M)
  2. extractionthe aqueous solution was extracted with EtOAc
  3. washThe organic layer was washed with brine
  4. dry with materialdried (Na2SO4)
  5. concentrationconcentrated
  6. customyielding 0.70 g (88%) of the sub-title substance

Sources & evidence

ORD record
ord-6e7c9ce51e8d43b188c613eed5821d7f
Source dataset
uspto-grants-2001_07
Patent number
US06265397B1

Reaction notes

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