Lithium hydroxide, monohydrate → HCID 18518705, compound

Participants

Reaction Steps

A solution of LiOH.H2O (0.95 g; 22.6 mmol) in water (30 mL) was added to a solution of 6-fluoro-4-hydroxychroman-4-yl-carboxylic acid, methyl ester (2.47 g; 10.9 mmol; from step (i) above) in THF (10 mL). The reaction mixture was stirred at room temperature for 2 days, THF was evaporated and the water phase was acidified with HCl (2M) and extracted with ethyl acetate. The organic layer was dried (Na2SO4) and evaporated, yielding the sub-title compound. Yield: 1.41 g (61%).

Provenance & Evidence