Potassium Iodide → HCID 21717337, compound

Participants

Reaction Steps

8-Amino-2,3-dimethylimidazo[1,2-a]pyridine (0.3 g, 1.86 mmol) and 2-ethyl-6-methylbenzylchloride (0.31 g, 1.84 mmol) were dissolved in 5 ml dimethoxyethane. Potassium iodide (0.2 g, 1.2 mmol) and Na2CO3 (0.3 g, 2.8 mmol) were added and the mixture was refluxed for 4 hours. The solvent was evaporated and the residue was purified by column chromatography on silica gel using a mixture of methylene chloride and ethyl acetate (60:40) as eluent. 230 mg (42%) of the title compound was obtained.

Provenance & Evidence