Sodium Chloride → 2,3-Dimethyl-8-(2,6-dimethyl-4-fluorobenzylamino)imidazo[1,2-a]pyridine

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Reaction Steps

8-Amino-2,3-dimethylimidazo[1,2-a]pyridine (0.5 g, 3.1 mmol) was dissolved in acetonitrile (6 ml). To the solution were added 2,6-dimethyl-4-fluoro-benzylbromide (0.67 g, 3.1 mmol) and potassium carbonate (0.47 g, 3.4 mmol). The mixture was refluxed for 16 h. Methylene chloride (12 ml) and a sodium chloride solution (20 ml) was added. The organic layer was separated, dried over sodium sulfate and evaporated under reduced pressure. The crude product was purified by chromatography (ethyl acetate:petroleum-ether 1:1). 400 mg of the title compound was obtained as a solid.

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