Sodium potassium tartrate tetrahydrate → HCID 21717333, compound

HRID 1386066Notes

Reaction equation

HRID 1386066 reaction equation
[C:1]([C:6]1[N:10]2[CH:11]=[C:12]([CH3:26])[CH:13]=[C:14]([NH:15][CH2:16][C:17]3[C:22]([CH3:23])=[CH:21][C:20]([F:24])=[CH:19][C:18]=3[CH3:25])[C:9]2=[N:8][C:7]=1[CH3:27])(OCC)=[O:2].O.O.O.O.C(C(C(C([O-])=O)O)O)([O-])=O.[K+].[Na+]>C1(C)C=CC=CC=1>[CH3:27][C:7]1[N:8]=[C:9]2[C:14]([NH:15][CH2:16][C:17]3[C:22]([CH3:23])=[CH:21][C:20]([F:24])=[CH:19][C:18]=3[CH3:25])=[CH:13][C:12]([CH3:26])=[CH:11][N:10]2[C:6]=1[CH2:1][OH:2]

Participants

4

Reactant 2

HCID 2724148Sodium potassium tartrate tetrahydrateHCID 22672644HCID 22672644, compound

Product 1

HCID 21717333HCID 21717333, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent3×

Procedure

A solution of 0.4 g (1.1 mmol) of 3-carboethoxy-2,6-dimethyl-8-(2,6-dimethyl-4-fluorobenzylamino)-imidazo[1,2-a]pyridine in 10 ml toluene was chilled with ice-water, (2.1 g, 6.6 mmol). Red-l 65% in toluene was added after 30 min. The solution was stirred for 2 h at room temperature. 10 ml of Rochelle-salt solution, (35 g sodium potassium tartrate tetrahydrate/250 ml water) was added dropwise, 10 ml toluene was added, the organic layer was separated, washed with water, dried over sodium sulfate and evaporated under reduced pressure.

Workup

  1. customthe organic layer was separated
  2. washwashed with water
  3. dry with materialdried over sodium sulfate
  4. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-8b12089bd5174e56af7d29a2d823d412
Source dataset
uspto-grants-2001_07
Patent number
US06265415B1

Reaction notes

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