Potassium Iodide → HCID 21717326, compound

Participants

Reaction Steps

A mixture of 4-chloro-2,6-dimethylbenzylbromide and 2-chloro-4,6-dimethylbenzylbromide (1.1 g, 4.68 mmol) and 8-amino-2,3-dimethylimidazo[1,2-a]pyridine (4.65 mmol) was dissolved in 15 ml dimethoxyethane. Potassium iodide (0.5 g, 3.0 mmol) and Na2CO3 (1 g, 9.4 mmol) was added. The mixture was refluxed for 4 hours. The solvent was evaporated and the residue was purified by column chromatography on silica gel. The product was eluted with a mixture of methylene chloride and ethyl acetate (70:30). 70 mg of the title compound was obtained.

Provenance & Evidence