Sodium Iodide → 2,3-Dimethyl-8-(2,6-dimethyl-4-fluorobenzyloxy)imidazo[1,2-a]pyridine

関与物質

役割	名称	HCID	仕込み量
反応物	Sodium Iodide	HCID 5238	—
反応物	Sodium Carbonate	HCID 10340	—
反応物	2,3-Dimethylimidazo[1,2-a]pyridin-8-ol	HCID 22467949	—
反応物	2-(Bromomethyl)-5-fluoro-1,3-dimethylbenzene	HCID 22672641	—
溶媒	Acetone	HCID 180	—
溶媒	Dichloromethane	HCID 6344	—
生成物	2,3-Dimethyl-8-(2,6-dimethyl-4-fluorobenzyloxy)imidazo[1,2-a]pyridine	HCID 21717321	—

反応手順

2,3-Dimethyl-8-hydroxyimidazo[1,2-a]pyridine (1.7 g, 10 mmol), 2,6-dimethyl-4-fluorobenzylbromide (2.3 g, 10 mmol), sodium iodide (0.5 g, 0.3 mmol) and sodium carbonate (2.6 g, 28 mmol) were added to acetone (75 ml) and the mixture was refluxed for 6 h. Methylene chloride was added and the mixture was filtered and the solvents were evaporated under reduced pressure. Purification by column chromatography on silica gel using methylene chloride:ethylacetate(1:2) as eluent gave the title compound as a white powder. (0.85 g, 28%)

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US06265415B1
出典データセット	uspto-grants-2001_07
ORD ID	ord-3b8a25f89b7141168becd8f094f7a95f
出典メモ	uspto-grants-2001_07