Hydrochloric Acid → 5-Fluoro-2,3-pyridinediamine

Participants

Reaction Steps

To a solution of 2-amino-5-fluoro-3-nitropyridine (0.42 g, 2.3 mmol) and iron powder (1.6 g, 28 mmol) in ethanol (10 ml) were added water (0.5 ml, 28 mmol) and hydrochloric acid (27 μl, 0.32 mmol). The mixture was refluxed for 1 h. An additional amount of iron powder (0.2 g, 3.6 mmol) was added and the mixture was refluxed for 30 min. The reaction mixture was filtered through celite and evaporation under reduced pressure of the solvent gave 0.3 g (100%) of the desired product.

Provenance & Evidence