反应详情

A solution of 2,3-diamino-5-bromopyridine (4.0 g, 21.29 mmol) and 3-bromo-2-butanone (3.7 g, 24.48 mmol) in ethanol (40 ml) was refluxed overnight. After cooling to room temperature, the crystalline product was filtered and washed with ethanol and ether. The crystals were dissolved in methylene chloride and neutralized by aqueous NaHCO3. The organic layer was separated, dried over Na2SO4 and evaporated in vacuo. Yield 2.3 g.

1. filtrationthe crystalline product was filtered
2. washwashed with ethanol and ether
3. dissolutionThe crystals were dissolved in methylene chloride
4. customThe organic layer was separated
5. dry with materialdried over Na2SO4
6. customevaporated in vacuo