HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-(4-Chlorobenzyl)-5,7-dihydroxy-4-methyl-2H-1-benzopyran-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Phloroglucinol | HCID 359 | — |
| Reactant | Ethyl 2-(4-chlorobenzyl)acetoacetate | HCID 2757404 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(4-Chlorobenzyl)-5,7-dihydroxy-4-methyl-2H-1-benzopyran-2-one | HCID 23500355 | — |
Reaction Steps
A solution of phloroglucinol (1.57 g) and ethyl 2-(4-chlorobenzyl)acetoacetate (3.18 g) in ethanol (25 ml) was treated with dry HCl at 0° C. for 1.5 hours and the solution was kept at that temperature overnight. Solvent was evaporated and the precipitate triturated with water. Yield 3.87 g (98%). Melting point 270-278° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06265421B1 |
| Source dataset | uspto-grants-2001_07 |
| ORD ID | ord-6a12390aba0a4a53ad5b4ce94fe90568 |
| Source note | uspto-grants-2001_07 |