Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Methanesulfonic Acid | HCID 6395 | — |
| Reactant | Tert-butyl acetoacetate | HCID 15538 | — |
| Reactant | 3,5-Dimethoxyaniline | HCID 66301 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | HCID 2794448 | HCID 2794448 | — |
Reaction Steps
tert-Butyl acetoacetate (1.58 g) was heated to 120° C. and 3,5-dimethoxyaniline (1.53 g) dissolved in xylene (4 ml) was added. The mixture was heated at 120-130° C. for 20 minutes and then cooled to room temperature. Methanesulfonic acid (2 ml) was added and the mixture was stirred at ambient temperature for 10 minutes. Water (40 ml) was added and the precipitate filtered and dried. Yield 1.31 g (60%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06265421B1 |
|---|
| Source dataset | uspto-grants-2001_07 |
|---|
| ORD ID | ord-7849328713464663824cc3bc1850ea67 |
|---|
| Source note | uspto-grants-2001_07 |
|---|
