Ethyl orthoformate → HCID 21717201, compound

Participants

Reaction Steps

A mixture of 5-bromooxindole (6.36 g, 30 mmol), (prepared according to J. Am. Chem. Soc. 1975, 67, 1656), and triethyl orthoformate (100 ml) was heated and stirred at reflux for 8 hours. The volatiles were removed by evaporation and the residue purified by column flash chromatography using petroleum ether/ether (7/3) as eluent. Evaporation of the solvents lead to a crystalline material which was collected, washed with a minimum of petroleum ether and dried under vacuum to give 5-bromo-1-diethoxymethyloxindole (6.43 g, 68%).

Provenance & Evidence