HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl orthoformate → HCID 21717300, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | 5-fluoro-1,3-dihydro-2H-indol-2-one | HCID 3731012 | — |
| Product | HCID 21717300 | HCID 21717300 | 40% |
Reaction Steps
A solution of 5-fluorooxindole (980 mg, 6.5 mmol), (prepared according to Synthesis 1993, 51), in triethyl orthoformate (25 ml) was stirred and heated at reflux for 8 hours. The volatiles were removed by evaporation and the crude product purified by flash chromatography using petroleum ether/ether 7/3 as eluent to give 5-fluoro-1-diethoxymethyloxindole (637 mg, 40%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06265411B1 |
| Source dataset | uspto-grants-2001_07 |
| ORD ID | ord-074e3d1fdeea43e181392dfd85fa6db7 |
| Source note | uspto-grants-2001_07 |