HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → HCID 21701573, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 135411164 | HCID 135411164 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 21701573 | HCID 21701573 | 83% |
Reaction Steps
A solution of 7-(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one (500 mg, 2.2 mmol) in thionyl chloride (15 ml) and DMF (0.1 ml) was heated at reflux for 3 hours. The volatiles were removed by evaporation to give 4-chloro-7-(2-methoxyethoxy)quinazoline hydrochloride as a cream solid (520 mg, 83%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06265411B1 |
| Source dataset | uspto-grants-2001_07 |
| ORD ID | ord-91cc3478958741339db52c532078744e |
| Source note | uspto-grants-2001_07 |