反应详情

7-Benzyloxy-3-methylthiooxindole (610 mg, 2.1 mmol), (EP 8226), was dissolved in hot ethanol (60 ml). The mixture was allowed to cool and Rainey Nickel (40 ml volume, prewashed with ethanol) was added and the mixture was stirred at ambient temperature for 1.5 hours. The insolubles were removed by filtration and the filter pad was thoroughly washed with ethanol. The solvent was removed from the filtrate by evaporation and the residue was purified by column chromatography eluting with ethyl acetate/petroleum ether (40/60) to give 7-benzyloxyoxindole (395 mg, 71%).

1. temperatureto cool
2. customThe insolubles were removed by filtration
3. washthe filter pad was thoroughly washed with ethanol
4. customThe solvent was removed from the filtrate by evaporation
5. customthe residue was purified by column chromatography
6. washeluting with ethyl acetate/petroleum ether (40/60)