HCID 21717241, compound → 1,1-Dimethylethyl 2-(2,3-dihydro-2-oxo-1H-indol-6-yl)-1-pyrrolidinecarboxylate

Participants

Reaction Steps

A mixture of 6-(1-t-butoxycarbonylpyrrol-2-yl)oxindole (560 mg, 1.9 mmol), (prepared as described for the starting material in Example 63), and 10% palladium-on-charcoal catalyst (50 mg) in ethyl acetate (30 ml) was stirred under hydrogen at 1 atmosphere pressure for 3 days. The catalyst was removed by filtration through diatomaceous earth, the solvent was removed by evaporation and the residue triturated with ether/isohexanes (1/5) and collected by filtration to give 6-(1-t-butoxycarbonylpyrrolidin-2-yl)oxindole (480 mg, 85%) as a pale yellow solid.

Provenance & Evidence