5-Methyl-2-thiophenecarboxaldehyde → HCID 178424458, compound

Participants

Reaction Steps

According to the method of Example 34, 6-[2-(1H-imidazole-4-yl)-ethoxy]-3,4-dihydro-2H-naphthalen-1-one, monohydrochloride (0.313 g, 1.07 mmol) was reacted with 5-methyl-2-thiophene carboxaldehyde (0.142 g, 1.13 mmol) in 5 mL of 4% KOH in EtOH overnight to afford 0.207 g (44%) of the title compound as a bright orange solid, mp 69-70° C.: CI-MS m/e 364 (M+), 365 (M++1).

Provenance & Evidence