alpha(or beta)-methyl-1H-imidazole-1-ethanol → 6-[2-(1H-1-Imidazolyl)propoxy]-1,2,3,4-tetrahydro-1-naphthalenone

Participants

Reaction Steps

Following the procedure of Example 76, but using 1.79 g (14.2 mmol) of 2-(1H-1-imidazolyl)-1-propanol and 2.0 g (12.3 mmol) of 6-[2-(1H-1-imidazolyl)ethoxy]-1,2,3,4-tetrahydro-1-naphthalenone, there was obtained 1.63 g (49% yield) of the product as a white solid, mp 132-135° C. The structure was confirmed by NMR and mass spectroscopy. MS m/z 271 (M+H+).

Provenance & Evidence