HCID 11492086, compound → 4-Cyano-2-fluorobenzoic acid

HRID 1386469Notes

Reaction equation

HRID 1386469 reaction equation
[C:1]([C:3]1[CH:13]=[CH:12][C:6]([C:7]([O:9]CC)=[O:8])=[C:5]([F:14])[CH:4]=1)#[N:2].ClC1C=C(C#N)C=CC=1C(OCC)=O>>[F:14][C:5]1[CH:4]=[C:3]([C:1]#[N:2])[CH:13]=[CH:12][C:6]=1[C:7]([OH:9])=[O:8]

Participants

3

Reactant 2

HCID 11492086HCID 11492086, compoundHCID 21717557HCID 21717557, compound

Product 1

HCID 5906594-Cyano-2-fluorobenzoic acidYield 100%

Procedure

In the same manner as in Example II-(41-2) except for using 0.58 g (3.0 mmol) of ethyl 4-cyano-2-fluorobenzoate tit in place of ethyl 2-chloro-4-cyanobenzoate, the reaction was carried out similarly to obtain 0.50 g (3.0 mmol) of the title compound as white crystal.

Sources & evidence

ORD record
ord-26c4d8f4d4bb4afb8ff6c719cdf14ed0
Source dataset
uspto-grants-2001_07
Patent number
US06265418B1

Reaction notes

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