HCID 21717622, compound → HCID 178439175, compound

Participants

Reaction Steps

1 equivalent of N,N′-carbonyldi-imidazole (Aldrich, 0.46 g, 0.29 mmol) is added, at ambient temperature to a solution of acid (E) 4-[1-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-2-propenyl]benzoic acid (0.10 g, 0.29 mmol) in 5 ml of anhydrous THF. Half an hour later, 1 equivalent of 5-aminotetrazole monohydrate (Aldrich, 0.30 g, 0.29 mmol) is added. The magnetic stirring is continued for 15 hours 30 minutes. A white precipitate forms in the reaction medium. The mixture is evaporated to dryness and 10 ml of HCl is added. The solution is filtered and the filtrate washed with water and with methanol. After drying one night in a desiccator (with P2O5), 15 mg of a white solid is obtained the compound (E) 4-[1-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-2-propenyl]-N-(tetrazol-5-yl)-benzamide (compound CB73364) (yield=12%).

Provenance & Evidence