Thionyl Chloride → Benzeneacetyl chloride, 4-bromo-

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Reaction Steps

Thionyl chloride (2.5 ml, 34.8 mmol) is added at ambient temperature to a solution of 4-bromophenylacetic acid (Aldrich, 5 g, 23.2 mmol) in 10 ml of toluene. The reaction medium is brought to reflux for 2 hours. After returning to ambient temperature, the toluene is evaporated and 5.55 g of raw 4-bromophenylacetyl chloride is obtained (gross yield=100%).

Provenance & Evidence