Methyl cyanoacetate → HCID 69972642, compound

HRID 1386499Notes

Reaction equation

[CH2:1]([C:3]([CH:5]1[CH2:7][CH2:6]1)=O)[CH3:2].[C:8]([CH2:10][C:11]([O:13][CH3:14])=[O:12])#[N:9]>>[C:8]([C:10](=[C:3]([CH:5]1[CH2:7][CH2:6]1)[CH2:1][CH3:2])[C:11]([O:13][CH3:14])=[O:12])#[N:9]

Participants

Reactant 2

HCID 7747Methyl cyanoacetate

HCID 5496991-Cyclopropyl-1-propanone

Product 1

HCID 69972642HCID 69972642, compoundYield 21%

Procedure

Similarly to Example 3a), a solution of 4 g (40.8 mmol) of cyclopropyl ethyl ketone and 2.4 g (24 mmol) of methyl cyanoacetate was reacted to give 0.9 g (21% yield) of methyl 2-cyano-3-cyclopropylpent-2-enoate.

Sources & evidence

ORD record: ord-073e11ffd89e4f0881d562dd882a97d6
Source dataset: uspto-grants-2001_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06265447B1

Reaction notes

Loading…