N-Methylbenzylamine → HCID 21181564, compound

Participants

Reaction Steps

To a mixture of the product compound of Example 8, Step (b) (508 mg, 2.00 mmoles), methyl benzylamine (484 mg, 4.00 mmoles), and tetra-n-butylamrnonium iodide (74 mg) in dry dimethylformamide (2.0 mL) was added anhydrous potassium carbonate (552 mg, 4.00 imol). The mixture was stirred overnight at 80-85°. After cooling, the mixture was partitioned between diethyl ether and water, the aqueous layer was extracted with ether, the combined organic extracts were washed with brine, dried over sodium sulfate, filtered and the solvent evaporated. Chromatography of the residue over silica gel using 25% ethyl acetate-hexane as eluent gave a compound (540 mg) as an oil which was characterized by NMR, as follows: 1H NMR(CD2Cl2) d 7.63-6.95(m, 9H), 1.22(d, 3H), 0.82(d, 3H).

Provenance & Evidence