p-Toluenesulfonic acid monohydrate → HCID 86757189, compound

Participants

Reaction Steps

A solution of 0.16 g of (E)-2′-[3-(diethylamino)propylsulphonyl]-2(R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-2′-isobutyl-4-methylvalerohydrazide in 4 ml of methanol was treated with 0.057 g of p-toluenesulphonic acid monohydrate. The mixture was stirred for 2 hours at room temperature and evaporated. Trituration of the residue with diethyl ether gave 0.125 g of (E)-2′-[3-(diethylamino)propylsulphonyl]-2(R)-[1(S)-(hydroxycarbamoyl)-4-phenyl-3-butenyl]-2′-isobutyl-4-methylvalerohydrazide p-toluenesulphonate in the form of an off-white solid.

Provenance & Evidence