HCID 86757194, compound → HCID 86757193, compound

Participants

Reaction Steps

A solution of 0.15 g of (E)-2′-(3-aminopropanesulphonyl)-2(R)-[1(S)-(benzyloxycarbamoyl)-4-phenyl-3-butenyl]-2′-isobutyl-4-methylvalerohydrazide in 5 ml of methanol was hydrogenated in the presence of 60 mg of 10% palladium-on-charcoal until uptake of hydrogen was complete. The catalyst was removed by filtration and the solvent was evaporated. The residue was triturated with diethyl ether and there was obtained 0.088 g of 2′-(3-aminopropanesulphonyl)-2(R)-[1(S)-(hydroxycarbamoyl)-4-phenylbutyl]-2′-isobutyl-4-methylvalerohydrazide in the form of a pale pink solid.

Provenance & Evidence