HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1386576Generated: October 30, 2026
Water → 4-[4-(4-Octyloxyphenyl)piperazin-1-yl]benzonitrile
https://huagongshe.com/reaction/1386576
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Fluorobenzonitrile | HCID 14517 | — |
| Reactant | 1-(4-(Octyloxy)phenyl)piperazine | HCID 21182348 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-[4-(4-Octyloxyphenyl)piperazin-1-yl]benzonitrile | HCID 21182245 | 82.9% |
Reaction Steps
To a suspension of 1-(4-n-Octyloxyphenyl)piperazine (1 g) and potassium carbonate (0.476 g) in N,N-dimethyl-formamide (1 ml) was added p-fluorobenzonitrile (0.347 g), and stirred for 5 hours at 160° C. The reaction mixture was added to a mixture of water and ethyl acetate. The organic layer was taken, and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure to give 4-[4-(4-n-Octyloxyphenyl)piperazin-1-yl]benzonitrile (0.93 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06265536B1 |
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| Source dataset | uspto-grants-2001_07 |
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| ORD ID | ord-ff846a51ac6f4cf5b6ac7fac1aef43f6 |
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| Source note | uspto-grants-2001_07 |
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