Ethyl bromoacetate → HCID 15550516, compound

Participants

Reaction Steps

The compound (5.13 g) of Example 1 was dissolved into DMF (70 ml) and, after adding sodium hydride (1.00 g), the mixture was stirred for 1 hour at room temperature. This was cooled in ice bath and ethyl 2-bromoacetate (2.77 ml) was added. After stirring for 18 hours until the temperature rose to room temperature, saturated aqueous solution of ammonium chloride was added and diluted with water, which was extracted with ether. After the organic layer was washed with water and with saturated brine and dried over anhydrous sodium sulfate, solvent was distilled off under reduced pressure. The residue was purified by means of silica gel column chromatography (developing solvent, ethyl acetate:n-hexane=1:2) to obtain aimed product (4.63 g) as a yellow oily product.

Provenance & Evidence