Water → HCID 21183033, compound

Participants

Reaction Steps

2-Isopropyl-3-phenacylpyrazolo[1,5-a]pyridine (1.90 g) was dissolved into DMF (30 ml), and, after adding sodium hydride (0.35 g), the mixture was stirred for 0.5 hours at room temperature. Methyl 2-bromoacetate (1.36 g) was added, and, after stirring the mixture for 3 hours at room temperature, saturated aqueous solution of ammonium chloride was added and diluted with water, which was extracted with ether. After the organic layer was washed with water and with saturated brine and dried over anhydrous sodium sulfate, solvent was distilled off under reduced pressure. The residue was purified by means of silica gel column chromatography (developing solvent, ethyl acetate:n-hexane=1:3) to obtain aimed product (1.58 g) as a yellow oily product.

Provenance & Evidence