HCID 21180727, compound → HCID 131722791, compound

Participants

Reaction Steps

The title compound was prepared from 24 mg (0.067 mmol) of 2-(R)-(3-(R)-formyl-4-(S)-phenylpyrrolidin-1-yl)-3-methylbutanoic acid, benzyl ester (from EXAMPLE 5, Step D) and 22.5 mg (0.073 mmol) of 4-hydroxy-4-(3-(quinolin-3-yl)propyl)piperidine.HCl from EXAMPLE 6, Step A using a procedure analogous to that described in EXAMPLE 1, Step J to provide 32.5 mg (75%) of the title compound: RF: 0.21 (19:1 v/v CH2Cl2/MeOH); 1H NMR (300 MHz) δ 0.88 (d, J=6.7,33H), 1.01 (d, J=6.7, 3H), 1.42-3.22 (m, 24H), 5.16 (ABq, 2H), 7.15-7.41 (m, 10H), 7.49-7.54 (m, 1H), 7.62-7.68 (m, 1H), 7.75 (d, J=8.0, 1H), 7.91 (s, 1H), 8.06 (d, J=8.2, 1H), 8.75 (d, J=2.1, 1H).

Provenance & Evidence