Hydrochloric Acid → 2-(3-(S)-((4-Hydroxy-4-(3-phenylpropyl)piperidin-1-yl)methyl)-4-(S)-phenylpyrrolidin-1-yl)acetic acid, benzyl ester

Participants

Reaction Steps

The title compound was prepared from 30 mg (0.094 mmol) of 2-(3-(R)-formyl-4-(S)-phenylpyrrolidin-1-yl)acetic acid, benzyl ester (from EXAMPLE 8, Step C) and 28 mg (0.10 mmol) of 4-hydroxy-4-(3-phenylpropyl)-piperidine.HCl using a procedure analogous to that described in EXAMPLE 1, Step J to provide 34.5 mg (70%) of the title compound: RF: 0.26 (19:1 v/v CH2Cl2/MeOH); 1H NMR (300 MHz) δ 1.24-1.69 (m, 8H), 2.16-3.14 (m, 14H), 3.43 (ABq, J=16.8, 2H), 5.16 (ABq, J=12.2, 2H), 7.15-7.37 (m, 15H).

Provenance & Evidence