Hydrochloric Acid → HCID 131722799, compound

Participants

Reaction Steps

The title compound was prepared from 22 mg (0.053 mmol) of 2-(R)-(3-(R)-formyl-4-(S)-phenylpyrrolidin-1-yl)-2-(cyclopentyl)acetic acid, 4-(methoxy)benzyl ester (from EXAMPLE 15, Step E) and 13 mg (0.054 mmol) of 4-(3-phenylpropyl)piperidine.HCl using a procedure analogous to that described in EXAMPLE 1, Step J to provide 26.5 mg (81%) of the title compound: RF: 0.25 (4:1 v/v hexanes/EtOAc); 1H NMR (300 MHz) δ 1.18-1.95 (m, 18H), 2.21-2.89 (m, 11H), 3.14-3.29 (m, 4H), 3.80 (s, 3H), 5.09 (ABq, J=11.9, 2H), 6.87 (d, J=8.7, 2H), 7.14-7.35 (m, 12H).

Provenance & Evidence