Hydrochloric Acid → 2-(R)-(3-(S)-((4-(3-(3,5-Difluorophenyl)propyl)piperidin-1-yl)methyl)-4-(S)-phenylpyrrolidin-1-yl)-3-(cyclobutyl)-propanoic acid, (4-methoxy)benzyl ester

Participants

Reaction Steps

The title compound was prepared from 19 mg (0.04 mmol) of 2-(R)-(3-(R)-formyl-4-(S)-phenylpyrrolidin-1-yl)-3-(cyclobutyl)propanoic acid, (4-methoxy)benzyl ester (from EXAMPLE 19, Step F) and 12.5 mg (0.04 mmol) of 4-(3-(3,5-difluorophenyl)propyl)piperidine.HCl (from EXAMPLE 95, Step E) using a procedure analogous to that described in EXAMPLE 1, Step J to provide 15.4 mg (53%) of the title compound: RF: 0.40 (1:1 v/v hexanes/EtOAc); 1H NMR (300 MHz) δ 1.04-3.27 (m, 33H), 3.80 (s, 3H), 5.04-5.13 (m, 2H), 6.57-6.69 (m, 21), 6.87 (d, J 8.8, 2H), 7.14-7.33 (m, 8H).

Provenance & Evidence