Hydrochloric Acid → 2-(R)-(3-(S)-((4-(3-(Benzofurazan-4-yl)-propyl)piperidin-1-yl)methyl)-4-(S)-phenylpyrrolidin-1-yl)-3-(cyclobutyl) propanoic acid, (4-methoxy)benzyl ester

Participants

Reaction Steps

The title compound was prepared from 20 mg (0.07 mmol) of 2-(R)-(3-(R)formyl-4-(S)-phenylpyrrolidin-1-yl)-3-(cyclobutyl)propanoic acid, (4-methoxy)benzyl ester (from EXAMPLE 19, Step F) and 13.7 mg (0.04 mmol) of 4-(3-(benzofurazanyl)propyl)piperidine.HCl (from EXAMPLE 117, Step B) using a procedure analogous to that described in EXAMPLE 1, Step J to provide 10.6 mg (35%) of the title compound: RF: 0.36 (1:1 v/v hexanes/EtOAc); 1H NMR (300 MHz) δ 0.80-3.32 (m, 33H), 3.80 (s, 31), 5.04-5.13 (m, 2H), 6.88 (d, J=8.6, 21), 7.15-7.37 (m, 8H), 7.51 (s, 1H), 7.73 (d, J=9.3, 1H).

Provenance & Evidence