Hydrochloric Acid → 2-(R)-(3-(S)-((4-(3-(3,4-Difluorophenyl)propyl)piperidin-1-yl)methyl)-4-(S)-phenylpyrrolidin-1-yl)-3-(cyclobutyl) propanoic acid, benzyl ester

Participants

Reaction Steps

The title compound was prepared from 26 mg (0.06 mmol) of 2-(R)-(3-(R)-formyl-4-(S)-phenylpyrrolidin-1-yl)-3-(cyclobutyl)propanoic acid, benzyl ester (from EXAMPLE 25, Step B) and 17.5 mg (0.06 mmol) of 4-(3-(3,4-difluorophenyl)propyl)piperidine.HCl (from EXAMPLE 119, Step C) using a procedure analogous to that described in EXAMPLE 1, Step J to provide 18.6 mg (47%) of the title compound: RF: 0.33 (1:1 v/v hexanes/EtOAc); 1H NMR (500 MHz) δ 1.15-3.29 (m, 33H), 5.17 (ABq, 2H), 6.8-7.4 (m, 13H).

Provenance & Evidence