alpha-(R)-(3-(R)-formyl-4-(S)-phenylpyrrolidin-1-yl)-cyclohexaneacetic acid 4-methoxybenzyl ester → HCID 131722806, compound

Participants

Reaction Steps

The title compound was prepared from 50 mg (0.11 mmol) of 2-(R)-(3-(R)-formyl-4-(S)-phenylpyrrolidin-1-yl)-2-(cyclohexyl)acetic acid, (4-methoxy)benzyl ester (from EXAMPLE 33, Step E) and 0.1 mol of 4-(3-((4-carbomethoxy)phenyl) propyl)piperidine TFA (from EXAMPLE 29, Step B) using a procedure analogous to that described in EXAMPLE 1, Step J to afford 33 mg (48%) of the title compound: 1H NMR (500 MHz), 0.60-1.28 (9H), 1.46-1.80 (11H), 1.95 (app d, J=13.0, 1H),2.18-2.36 (3H), 2.54 (dd, J=6.5,9.0, 1H), 2.60-2.64 (m, 2H), 2.66 (t, J=8.5, 2H), 2.77-2.82 (m, 2H), 3.13-3.21 (3H), 3.80 (s, 3H), 3.90 (s, 3H), 5.09 (ABq, J=12.0, 2H), 6.87 (d, J=9.0, 2H), 7.15-7.23 (5H), 7.25 (d, J=7.0, 2H), 7.32 (d, J=9.0,21), 7.93 (d, J=7.0, 2H).

Provenance & Evidence