Triphenylphosphine → HCID 20672428, compound

Participants

Reaction Steps

A solution of 1.56 g (4.4 mmol) of 1-iodo-2-(S)-((t-butoxycarbonyl)piperidin-4-yl)propane (from EXAMPLE 30, Step E) and 1.31 g (5.0 mmol) of triphenylphosphine in 5 mL of CH3CN was heated at reflux for 48 h. The mixture was cooled and concentrated. The residue was triturated with ether and CH2Cl2 and the resulting solid filtered and dried to afford 1.97 g (72%) of the title compound.

Provenance & Evidence