Dichloromethane methanol ammonium hydroxide → HCID 20672346, compound

Participants

Reaction Steps

The title compound was prepared from 58 mg (0.093 mmol) of 2-(R)-(3-(S)-((4-(3-(2-pyridyl)propyl)piperidin-1-yl)methyl)-4-(S)-phenylpyrrolidin-1-yl)-2-(cyclohexyl)acetic acid, (4-methoxy)benzyl ester (from EXAMPLE 72, Step C) using a procedure analogous to that described in EXAMPLE 10, Step F. Flash chromatography using 90:10:1 v/v/v CH2Cl2/MeOH/NH4OH as the eluant afforded 44 mg (94%) of the title compound: 1H NMR (500 MHz) δ 0.82-3.90 (35H), 7.07-7.58 (8H), 8.49 (d, J=4.8 Hz, 11H); ESI-MS 504 (M+H).

Provenance & Evidence